abstract：:The functional significance of vestibular information for the generation of gaze shifts is controversial and less well established than the vestibular contribution to gaze stability. In this study, we asked seven bilaterally avestibular patients to execute voluntary, whole body pivot turns to visual targets up to 180°...

journal_title：Journal of neurophysiology

authors： Anastasopoulos D,Ziavra N,Bronstein AM

更新日期：2019-11-01 00:00:00

abstract：:Electrophysiological analysis has revealed much about the broad coding and neural ensemble dynamics that characterize gustatory cortical (GC) taste processing in awake rats and about how these dynamics relate to behavior. With regard to mice, however, data concerning cortical taste coding have largely been restricted ...

journal_title：Journal of neurophysiology

authors： Levitan D,Lin JY,Wachutka J,Mukherjee N,Nelson SB,Katz DB

更新日期：2019-10-01 00:00:00

abstract：:Microglia constitute ~10-20% of glial cells in the adult human brain. They are the resident phagocytic immune cells of the central nervous system and play an integral role as first responders during inflammation. Microglia are commonly classified as "HM" (homeostatic), "M1" (classically activated proinflammatory), or ...

journal_title：Journal of neurophysiology

authors： von Maydell D,Jorfi M

更新日期：2019-10-01 00:00:00

abstract：:Humans quickly and sophisticatedly correct their movements in response to changes in the world, such as when reaching to a target that abruptly changes its location. The vigor of these movement corrections is time-dependent, increasing if the time left to make the correction decreases, which can be explained by optima...

journal_title：Journal of neurophysiology

authors： Oostwoud Wijdenes L,van Beers RJ,Medendorp WP

更新日期：2019-09-01 00:00:00

abstract：:Active sensing in biological system consists of emitting/receiving a periodic signal to explore the environment. The signal can be emitted toward distant objects, as in echolocation, or in direct contact with the object, for example, whisking in rodents. We explored the hypothesis that a similar mechanism exists in hu...

journal_title：Journal of neurophysiology

authors： Dione M,Wessberg J

更新日期：2019-09-01 00:00:00

abstract：:The potassium-chloride cotransporter 2 (KCC2) plays a role in epileptiform synchronization, but it remains unclear how it influences such a process. Here, we used tetrode recordings in the in vitro rat entorhinal cortex (EC) to analyze the effects of the KCC2 antagonist VU0463271 on 4-aminopyridine (4AP)-induced ictal...

journal_title：Journal of neurophysiology

authors： Chen LY,Lévesque M,Avoli M

更新日期：2019-09-01 00:00:00

abstract：:High-frequency burstlike electrical conditioning stimulation (HFS) applied to human skin induces an increase in mechanical pinprick sensitivity of the surrounding unconditioned skin (a phenomenon known as secondary hyperalgesia). The present study assessed the effect of frequency of conditioning stimulation on the dev...

journal_title：Journal of neurophysiology

authors： van den Broeke EN,Gousset S,Bouvy J,Stouffs A,Lebrun L,van Neerven SGA,Mouraux A

更新日期：2019-09-01 00:00:00

abstract：:The caudal primate prefrontal cortex (PFC) is involved in target selection and visually guided saccades through both covert attention and overt orienting eye movements. Unilateral damage to the caudal PFC often leads to decreased awareness of a contralesional target alone, referred to as "neglect," or when it is prese...

journal_title：Journal of neurophysiology

authors： Adam R,Johnston K,Everling S

更新日期：2019-08-01 00:00:00

abstract：:While it has been well established that optostatic and optokinetic cues contribute to the perception of vertical, it is unclear how the brain processes their combined presence with the nonvisual vestibular cues. Using a psychometric approach, we examined the percept of vertical in human participants (n = 17) with thei...

journal_title：Journal of neurophysiology

authors： Niehof N,Perdreau F,Koppen M,Medendorp WP

更新日期：2019-08-01 00:00:00

abstract：:How neurons filter and integrate their complex patterns of synaptic inputs is central to their role in neural information processing. Synaptic filtering and integration are shaped by the frequency-dependent neuronal membrane impedance. Using single and dual dendritic recordings in vivo, pharmacology, and computational...

journal_title：Journal of neurophysiology

authors： Dewell RB,Gabbiani F

更新日期：2019-08-01 00:00:00

abstract：:The auditory frequency-following response (FFR) reflects synchronized and phase-locked activity along the auditory pathway in response to sound. Although FFRs were historically thought to reflect subcortical activity, recent evidence suggests an auditory cortex contribution as well. Here we present electrophysiologica...

journal_title：Journal of neurophysiology

authors： White-Schwoch T,Anderson S,Krizman J,Nicol T,Kraus N

更新日期：2019-08-01 00:00:00

abstract：:Organization of spinal motor output has become of interest for investigating differential activation of lumbar and sacral motor pools during locomotor tasks. Motor pools are associated with functional grouping of motoneurons of the lower limb muscles. Here we examined how the spatiotemporal organization of lumbar and ...

journal_title：Journal of neurophysiology

authors： Dewolf AH,Ivanenko YP,Zelik KE,Lacquaniti F,Willems PA

更新日期：2019-08-01 00:00:00

abstract：:Several qualitative features distinguish bipedal from quadrupedal locomotion in mammals. In this study we show quantitative differences between quadrupedal and bipedal gait in the Japanese monkey in terms of gait patterns, trunk/hindlimb kinematics, and electromyographic (EMG) activity, obtained from 3 macaques during...

journal_title：Journal of neurophysiology

authors： Higurashi Y,Maier MA,Nakajima K,Morita K,Fujiki S,Aoi S,Mori F,Murata A,Inase M

更新日期：2019-07-01 00:00:00

abstract：:Frequent gait modifications are often required to navigate our world. These can involve long or wide steps or changes in direction. People generally prefer to minimize the motor cost (or effort) of a movement, although with changes in gait this is not always possible. The decision of when and where to shift gaze is cr...

journal_title：Journal of neurophysiology

authors： Domínguez-Zamora FJ,Marigold DS

更新日期：2019-07-01 00:00:00

abstract：:Previous studies have shown that regional slow-wave activity (SWA) during non-rapid eye movement (NREM) sleep is modulated by prior experience and learning. Although this effect has been convincingly demonstrated for the sensorimotor domain, attempts to extend these findings to the visual system have provided mixed re...

journal_title：Journal of neurophysiology

authors： Bernardi G,Betta M,Cataldi J,Leo A,Haba-Rubio J,Heinzer R,Cirelli C,Tononi G,Pietrini P,Ricciardi E,Siclari F

更新日期：2019-06-01 00:00:00

abstract：:Studying adaptation to Coriolis perturbations of arm movements has advanced our understanding of motor control and learning. We have now applied this paradigm to two-dimensional postural sway. We measured how subjects (n = 8) standing at the center of a fully enclosed rotating room who made voluntary anterior-posterio...

journal_title：Journal of neurophysiology

authors： Bakshi A,DiZio P,Lackner JR

更新日期：2019-06-01 00:00:00

abstract：:Multimodal sensory integration facilitates the generation of a unified and coherent perception of the environment. It is now well established that unimodal sensory perceptions, such as vision, are improved in multisensory contexts. Whereas multimodal integration is primarily performed by dedicated multisensory brain r...

journal_title：Journal of neurophysiology

authors： McClure JP Jr,Polack PO

更新日期：2019-06-01 00:00:00

abstract：:We have previously shown that sinusoidal galvanic vestibular stimulation (sGVS), delivered at 0.2-2.0 Hz, evokes a partial entrainment of muscle sympathetic nerve activity (MSNA). Moreover, at lower frequencies of stimulation (0.08-0.18 Hz) sGVS produces two peaks of modulation: one (primary) peak associated with the ...

journal_title：Journal of neurophysiology

authors： Singh N,Hammam E,Macefield VG

更新日期：2019-05-01 00:00:00

abstract：:Fear conditioning studies have led to the view that the amygdala contains neurons that signal threat and in turn elicit defensive behaviors through their brain stem and hypothalamic targets. In agreement with this model, a prior unit-recording study in rats performing a seminaturalistic foraging task revealed that man...

journal_title：Journal of neurophysiology

authors： Amir A,Kyriazi P,Lee SC,Headley DB,Paré D

更新日期：2019-05-01 00:00:00

abstract：:Searching for items that are useful given current goals, or "target" recognition, requires observers to flexibly attend to certain object properties at the expense of others. This could involve focusing on the identity of an object while ignoring identity-preserving transformations such as changes in viewpoint or focu...

journal_title：Journal of neurophysiology

authors： Henderson M,Serences JT

更新日期：2019-04-01 00:00:00

abstract：:Since sensory systems operate with a finite quantity of processing resources, an animal would benefit from prioritizing processing of sensory stimuli within a time window that is expected to provide key information. This behavioral manifestation of such prioritization is known as attention. Here, we investigate attent...

journal_title：Journal of neurophysiology

authors： Lee CCY,Clifford CWG,Arabzadeh E

更新日期：2019-03-01 00:00:00

abstract：:Foot drop is very common among people with chronic incomplete spinal cord injury (SCI) and likely stems from SCI that disturbs the corticospinal activation of the ankle dorsiflexor tibialis anterior (TA). Thus, if one can recover or increase the corticospinal excitability reduced by SCI, motor function recovery may be...

journal_title：Journal of neurophysiology

authors： Thompson AK,Fiorenza G,Smyth L,Favale B,Brangaccio J,Sniffen J

更新日期：2019-03-01 00:00:00

abstract：:Hyperphagia is common in diabetes and may worsen hyperglycemia and diabetic complications. The responsible mechanisms are not well understood. The hypothalamus is a key center for the control of appetite and energy homeostasis. The ventromedial nucleus (VMH) and arcuate nucleus (ARC) are two critical nuclei involved i...

journal_title：Journal of neurophysiology

authors： Li JY,Wu X,Lee A,Zhou SY,Owyang C

更新日期：2019-03-01 00:00:00

abstract：:Synaptic currents are frequently assumed to make a major contribution to the extracellular field potential (EFP). However, in any neuronal population, the explicit separation of synaptic sources from other contributions such as postsynaptic spikes remains a challenge. Here we take advantage of the simple organization ...

journal_title：Journal of neurophysiology

authors： McColgan T,Kuokkanen PT,Carr CE,Kempter R

更新日期：2019-03-01 00:00:00

abstract：:We report a novel phenomenon produced by focused ultrasound (US) that may be important for understanding its effects on cell membranes. When a US burst (2.1 MHz, 1-mm focal diameter, 0.1-1 MPa) was focused on a motor axon of the crayfish neuromuscular junction, it consistently produced a fast hyperpolarization, which ...

journal_title：Journal of neurophysiology

authors： Lin JW,Yu F,Müller WS,Ehnholm G,Okada Y

更新日期：2019-02-01 00:00:00

abstract：:The lateral hypothalamus (LH), which plays a role in homeostatic functions such as appetite regulation, is also linked to arousal and motivational behavior. However, little is known about how these components are encoded in the LH. Thus cynomolgus monkeys were conditioned with two distinct contexts, i.e., an appetitiv...

journal_title：Journal of neurophysiology

authors： Noritake A,Nakamura K

更新日期：2019-02-01 00:00:00

abstract：:Hippocampal mossy fiber axons simultaneously activate CA3 pyramidal cells and stratum lucidum interneurons (SLINs), the latter providing feedforward inhibition to control CA3 pyramidal cell excitability. Filopodial extensions of giant boutons of mossy fibers provide excitatory synaptic input to the SLIN. These filopod...

journal_title：Journal of neurophysiology

authors： Pan E,Zhao Z,McNamara JO

更新日期：2019-02-01 00:00:00

abstract：:Motor imagery (MI) is a promising rehabilitation technique that has received significant interest for use in persons with multiple sclerosis (MS). Through alterations in neural networks, MI has the potential to improve measures of walking speed, walking distance, and fatigue in people with MS. Further research is requ...

journal_title：Journal of neurophysiology

authors： Hanson M,Concialdi M

更新日期：2019-02-01 00:00:00

abstract：:Procedural skill learning requires iterative comparisons between feedback of self-generated motor output and a goal sensorimotor pattern. In juvenile songbirds, neural representations of both self-generated behaviors (each bird's own immature song) and the goal motor pattern (each bird's adult tutor song) are essentia...

journal_title：Journal of neurophysiology

authors： Yuan RC,Bottjer SW

更新日期：2019-02-01 00:00:00

abstract：:Two main types of small eye movements occur during gaze fixation: microsaccades and slow ocular drifts. While microsaccade generation has been relatively well studied, ocular drift control mechanisms are unknown. Here we explored the degree to which monkey smooth eye movements, on the velocity scale of slow ocular dri...

journal_title：Journal of neurophysiology

authors： Skinner J,Buonocore A,Hafed ZM

更新日期：2019-02-01 00:00:00

abstract：:Rodents shift their nose from side to side when they actively explore and lateralize odors in the space. This motor action is driven by a pair of muscles, the deflector nasi. We studied the premotor control of this motion. We used replication-competent rabies virus to transsynaptically label inputs to the deflector na...

journal_title：Journal of neurophysiology

authors： Kurnikova A,Deschênes M,Kleinfeld D

更新日期：2019-01-01 00:00:00

abstract：:Recent studies have shown that sympathetic nervous system (SNS) activity can be heavily impacted not only by basic threats to survival but also by threats to social bonds. In this study we explored the behavioral and physiological consequences of social exclusion/inclusion in patients with psoriasis, a disease frequen...

journal_title：Journal of neurophysiology

authors： Ponsi G,Monachesi B,Panasiti V,Aglioti SM,Panasiti MS

更新日期：2019-01-01 00:00:00

abstract：:The external anal sphincter (EAS) is important for the maintenance of bowel continence and may be compromised by a variety of neuropathic conditions. However, large animal models for the study of EAS functions have been sparse. The EAS guarding reflex was examined by electromyography (EMG) in neurologically intact rhe...

journal_title：Journal of neurophysiology

authors： Chang HH,Lee U,Vu T,Pikov V,Nieto JH,Christe KL,Havton LA

更新日期：2018-12-01 00:00:00

abstract：:During anticipated postural perturbations induced by limb movement, the central nervous system generates anticipatory postural adjustments (APAs) in the trunk and hip musculature to minimize disturbances to equilibrium. Age-related changes in functional organization of the nervous system may contribute to changes in A...

journal_title：Journal of neurophysiology

authors： Smith JA,Fisher BE

更新日期：2018-12-01 00:00:00

abstract：:Precise motion control is critical to human survival on Earth and in space. Motion sensation is inherently imprecise, and the functional implications of this imprecision are not well understood. We studied a "vestibular" manual control task in which subjects attempted to keep themselves upright with a rotational hand ...

journal_title：Journal of neurophysiology

authors： Rosenberg MJ,Galvan-Garza RC,Clark TK,Sherwood DP,Young LR,Karmali F

更新日期：2018-12-01 00:00:00

abstract：:Overestimation of roll tilt in hypergravity ("G-excess" illusion) has been demonstrated, but corresponding sustained hypogravic conditions are impossible to create in ground laboratories. In this article we describe the first systematic experimental evidence that in a hypogravity analog, humans underestimate roll tilt...

journal_title：Journal of neurophysiology

authors： Galvan-Garza RC,Clark TK,Sherwood D,Diaz-Artiles A,Rosenberg M,Natapoff A,Karmali F,Oman CM,Young LR

更新日期：2018-12-01 00:00:00

abstract：:Action observation activates brain regions involved in sensory-motor control. Recent research has shown that action observation can also facilitate motor learning; observing a tutor undergoing motor learning results in functional plasticity within the motor system and gains in subsequent motor performance. However, th...

journal_title：Journal of neurophysiology

authors： McGregor HR,Cashaback JGA,Gribble PL

更新日期：2018-12-01 00:00:00

abstract：:Humans engage in many daily activities that rely on working memory, the ability to hold and sequence information temporarily to accomplish a task. We focus on the process of working memory, based on circuit mechanisms for attending to relevant signals and suppressing irrelevant stimuli. We discuss that connections cri...

journal_title：Journal of neurophysiology

authors： Barbas H,Wang J,Joyce MKP,García-Cabezas MÁ

更新日期：2018-11-01 00:00:00

abstract：:Subfornical organ (SFO) neurons exhibit heterogeneity in current expression and spiking behavior, where the two major spiking phenotypes appear as tonic and burst firing. Insight into the mechanisms behind this heterogeneity is critical for understanding how the SFO, a sensory circumventricular organ, integrates and s...

journal_title：Journal of neurophysiology

authors： Medlock L,Shute L,Fry M,Standage D,Ferguson AV

更新日期：2018-11-01 00:00:00

abstract：:Recent findings indicate that monkeys can report their confidence in perceptual decisions and that this information is encoded in neurons involved in making decisions, including the lateral intraparietal area (LIP) and the supplementary eye field (SEF). A key issue to consider when studying confidence is that decision...

journal_title：Journal of neurophysiology

authors： Grimaldi P,Cho SH,Lau H,Basso MA

更新日期：2018-11-01 00:00:00